[
  {
    "id": "egfr-ig",
    "label": "EGFR",
    "label_zh": "表皮生长因子受体",
    "category": "egfr-imagegen",
    "description": "Generated flat mechanism icon for EGFR; domain-level teaching schematic.",
    "scope": "Generic teaching geometry. Domain regions and source-pixel contact anchors are curated; no atomic interface is claimed.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/simplified-mapkerk-signalling",
        "scope": "Public preview visually inspected for composition and detail; no paths copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/12297050/",
        "scope": "Primary abstract/record for domain role and interaction."
      },
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/16777603/",
        "scope": "Primary abstract/record for domain role and interaction."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "egfr-imagegen/sources/egfr-ig.png",
      "prompt": "egfr-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "egfr-imagegen/egfr-ig.svg",
    "parts": [
      "outline",
      "ectodomain-stem",
      "kinase-domain",
      "C-terminal-tail"
    ],
    "anchors": {
      "EGF-binding": {
        "point": [
          79.22609331859881,
          38.608695652173914
        ],
        "normal": [
          -1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "EGF-EGFR",
          "shape": "socket",
          "halfWidth": 1.4285714285714286,
          "depth": 0.28571428571428575,
          "profile": "continuous-body",
          "framePoint": [
            78.98050974512745,
            38.608695652173914
          ],
          "schematic": true
        }
      },
      "dimer-arm": {
        "point": [
          98.75862068965517,
          35.040479760119936
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "EGFR-dimer",
          "shape": "flat",
          "halfWidth": 1.0714285714285714,
          "depth": 0.0,
          "profile": "continuous-body",
          "framePoint": [
            98.75862068965517,
            35.040479760119936
          ],
          "schematic": true
        }
      },
      "membrane": {
        "point": [
          77.14542728635683,
          90.50074962518741
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "membrane"
      },
      "pY-tail": {
        "point": [
          91.31634182908547,
          148.07112299819465
        ],
        "normal": [
          0,
          1
        ],
        "kind": "binding",
        "interface": {
          "id": "pY-SH2",
          "shape": "tab",
          "halfWidth": 0.5357142857142857,
          "depth": 0.28571428571428575,
          "profile": "continuous-body",
          "framePoint": [
            91.31634182908547,
            147.7961019490255
          ],
          "schematic": true
        }
      },
      "kinase": {
        "point": [
          87.23838080959521,
          114.76461769115443
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding"
      }
    },
    "palette": {
      "outline": "#3D5963",
      "ectodomain-stem": "#69ADB5",
      "kinase-domain": "#B2A6CD",
      "C-terminal-tail": "#E4BE78"
    },
    "source_to_svg": {
      "scale": 0.10194902548725637,
      "translate": [
        25.661169415292356,
        1.6011994002998478
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 2.8,
      "patches": false,
      "source_preserved": true
    }
  },
  {
    "id": "egf-ig",
    "label": "EGF",
    "label_zh": "表皮生长因子",
    "category": "egfr-imagegen",
    "description": "Generated flat mechanism icon for EGF; domain-level teaching schematic.",
    "scope": "Generic teaching geometry. Domain regions and source-pixel contact anchors are curated; no atomic interface is claimed.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/simplified-mapkerk-signalling",
        "scope": "Public preview visually inspected for composition and detail; no paths copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/12297050/",
        "scope": "Primary abstract/record for domain role and interaction."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "egfr-imagegen/sources/egf-ig.png",
      "prompt": "egfr-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "egfr-imagegen/egf-ig.svg",
    "parts": [
      "outline",
      "ligand"
    ],
    "anchors": {
      "receptor-contact": {
        "point": [
          149.0132441761997,
          85.84375
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "EGF-EGFR",
          "shape": "tab",
          "halfWidth": 6.666666666666667,
          "depth": 1.3333333333333335,
          "profile": "continuous-body",
          "framePoint": [
            147.8671875,
            85.84375
          ],
          "schematic": true
        }
      }
    },
    "palette": {
      "outline": "#3D5963",
      "ligand": "#E4BE78"
    },
    "source_to_svg": {
      "scale": 0.1328125,
      "translate": [
        -22.0,
        11.8671875
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 0.6,
      "patches": false,
      "source_preserved": true
    }
  },
  {
    "id": "grb2-ig",
    "label": "GRB2",
    "label_zh": "衔接蛋白 GRB2",
    "category": "egfr-imagegen",
    "description": "Generated flat mechanism icon for GRB2; domain-level teaching schematic.",
    "scope": "Generic teaching geometry. Domain regions and source-pixel contact anchors are curated; no atomic interface is claimed.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/simplified-mapkerk-signalling",
        "scope": "Public preview visually inspected for composition and detail; no paths copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/8479541/",
        "scope": "Primary abstract/record for domain role and interaction."
      },
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/8479540/",
        "scope": "Primary abstract/record for domain role and interaction."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "egfr-imagegen/sources/grb2-ig.png",
      "prompt": "egfr-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "egfr-imagegen/grb2-ig.svg",
    "parts": [
      "outline",
      "SH3-domains",
      "SH2-domain"
    ],
    "anchors": {
      "SH2": {
        "point": [
          81.08510638297872,
          70.86871764882748
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "binding",
        "interface": {
          "id": "pY-SH2",
          "shape": "socket",
          "halfWidth": 1.7647058823529411,
          "depth": 0.9411764705882354,
          "profile": "continuous-body",
          "framePoint": [
            81.08510638297872,
            69.9627659574468
          ],
          "schematic": true
        }
      },
      "SH3-right": {
        "point": [
          139.63329892616719,
          80.90425531914893
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "SH3-SOS1",
          "shape": "tab",
          "halfWidth": 8.23529411764706,
          "depth": 0.9411764705882354,
          "profile": "continuous-body",
          "framePoint": [
            138.86702127659575,
            80.90425531914893
          ],
          "schematic": true
        }
      }
    },
    "palette": {
      "outline": "#3D5963",
      "SH3-domains": "#69ADB5",
      "SH2-domain": "#E4BE78"
    },
    "source_to_svg": {
      "scale": 0.09042553191489362,
      "translate": [
        -0.026595744680861344,
        39.85106382978723
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 0.85,
      "patches": false,
      "source_preserved": true
    }
  },
  {
    "id": "sos1-ig",
    "label": "SOS1",
    "label_zh": "鸟嘌呤核苷酸交换因子 SOS1",
    "category": "egfr-imagegen",
    "description": "Generated flat mechanism icon for SOS1; domain-level teaching schematic.",
    "scope": "Generic teaching geometry. Domain regions and source-pixel contact anchors are curated; no atomic interface is claimed.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/simplified-mapkerk-signalling",
        "scope": "Public preview visually inspected for composition and detail; no paths copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/8479541/",
        "scope": "Primary abstract/record for domain role and interaction."
      },
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/9690470/",
        "scope": "Primary abstract/record for domain role and interaction."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "egfr-imagegen/sources/sos1-ig.png",
      "prompt": "egfr-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "egfr-imagegen/sos1-ig.svg",
    "parts": [
      "outline",
      "catalytic-region",
      "proline-rich-region"
    ],
    "anchors": {
      "GRB2-contact": {
        "point": [
          12.64521665221809,
          122.33333333333334
        ],
        "normal": [
          -1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "SH3-SOS1",
          "shape": "socket",
          "halfWidth": 6.934234482228935,
          "depth": 0.792483940826164,
          "profile": "continuous-body",
          "framePoint": [
            12.0,
            122.33333333333334
          ],
          "schematic": true
        }
      },
      "RAS-exchange": {
        "point": [
          148.5281011489875,
          45.400000000000006
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "SOS1-RAS",
          "shape": "tab",
          "halfWidth": 8.915444334294346,
          "depth": 0.792483940826164,
          "profile": "continuous-body",
          "framePoint": [
            147.86666666666667,
            45.400000000000006
          ],
          "schematic": true
        }
      }
    },
    "palette": {
      "outline": "#3D5963",
      "catalytic-region": "#69ADB5",
      "proline-rich-region": "#E4BE78"
    },
    "source_to_svg": {
      "scale": 0.13333333333333333,
      "translate": [
        -9.733333333333334,
        1.6666666666666714
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 1.0094841785260664,
      "patches": false,
      "source_preserved": true
    }
  },
  {
    "id": "ras-ig",
    "label": "RAS",
    "label_zh": "膜上小 GTP 酶 RAS",
    "category": "egfr-imagegen",
    "description": "Generated flat mechanism icon for RAS; domain-level teaching schematic.",
    "scope": "Generic teaching geometry. Domain regions and source-pixel contact anchors are curated; no atomic interface is claimed.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/simplified-mapkerk-signalling",
        "scope": "Public preview visually inspected for composition and detail; no paths copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/9690470/",
        "scope": "Primary abstract/record for domain role and interaction."
      },
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/8332195/",
        "scope": "Primary abstract/record for domain role and interaction."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "egfr-imagegen/sources/ras-ig.png",
      "prompt": "egfr-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "egfr-imagegen/ras-ig.svg",
    "parts": [
      "outline",
      "GTPase-body",
      "membrane-anchor"
    ],
    "anchors": {
      "membrane": {
        "point": [
          78.6247191011236,
          13.06966292134831
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "membrane"
      },
      "SOS-contact": {
        "point": [
          28.375237885586575,
          89.32134831460674
        ],
        "normal": [
          -1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "SOS1-RAS",
          "shape": "socket",
          "halfWidth": 8.571428571428571,
          "depth": 0.7619047619047619,
          "profile": "continuous-body",
          "framePoint": [
            27.73932584269663,
            89.32134831460674
          ],
          "schematic": true
        }
      },
      "RAF-contact": {
        "point": [
          57.68988764044944,
          147.53380548492223
        ],
        "normal": [
          0,
          1
        ],
        "kind": "binding",
        "interface": {
          "id": "RAS-RAF",
          "shape": "tab",
          "halfWidth": 4.761904761904762,
          "depth": 0.7619047619047619,
          "profile": "continuous-body",
          "framePoint": [
            57.68988764044944,
            146.9303370786517
          ],
          "schematic": true
        }
      }
    },
    "palette": {
      "outline": "#3D5963",
      "GTPase-body": "#69ADB5",
      "membrane-anchor": "#E4BE78"
    },
    "source_to_svg": {
      "scale": 0.15280898876404495,
      "translate": [
        -23.757303370786516,
        -2.669662921348319
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 1.05,
      "patches": false,
      "source_preserved": true
    }
  },
  {
    "id": "raf-ig",
    "label": "RAF1",
    "label_zh": "RAF1 丝氨酸苏氨酸激酶",
    "category": "egfr-imagegen",
    "description": "Generated flat mechanism icon for RAF1; domain-level teaching schematic.",
    "scope": "Generic teaching geometry. Domain regions and source-pixel contact anchors are curated; no atomic interface is claimed.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/simplified-mapkerk-signalling",
        "scope": "Public preview visually inspected for composition and detail; no paths copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/8332195/",
        "scope": "Primary abstract/record for domain role and interaction."
      },
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/1322500/",
        "scope": "Primary abstract/record for domain role and interaction."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "egfr-imagegen/sources/raf-ig.png",
      "prompt": "egfr-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "egfr-imagegen/raf-ig.svg",
    "parts": [
      "outline",
      "regulatory-region",
      "kinase-region"
    ],
    "anchors": {
      "RAS-binding": {
        "point": [
          65.6503937007874,
          12.55099289268179
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "binding",
        "interface": {
          "id": "RAS-RAF",
          "shape": "socket",
          "halfWidth": 4.347826086956522,
          "depth": 0.6956521739130436,
          "profile": "continuous-body",
          "framePoint": [
            65.6503937007874,
            11.999999999999996
          ],
          "schematic": true
        }
      },
      "MEK-substrate": {
        "point": [
          100.98897637795275,
          148.02629655352823
        ],
        "normal": [
          0,
          1
        ],
        "kind": "binding",
        "interface": {
          "id": "RAF-MEK",
          "shape": "tab",
          "halfWidth": 6.9565217391304355,
          "depth": 0.6956521739130436,
          "profile": "continuous-body",
          "framePoint": [
            100.98897637795275,
            147.46456692913387
          ],
          "schematic": true
        }
      }
    },
    "palette": {
      "outline": "#3D5963",
      "regulatory-region": "#69ADB5",
      "kinase-region": "#B2A6CD"
    },
    "source_to_svg": {
      "scale": 0.10708661417322834,
      "translate": [
        24.100787401574806,
        -0.9574803149606339
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 1.15,
      "patches": false,
      "source_preserved": true
    }
  },
  {
    "id": "mek-ig",
    "label": "MEK1/2",
    "label_zh": "MEK 双特异性激酶",
    "category": "egfr-imagegen",
    "description": "Generated flat mechanism icon for MEK1/2; domain-level teaching schematic.",
    "scope": "Generic teaching geometry. Domain regions and source-pixel contact anchors are curated; no atomic interface is claimed.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/simplified-mapkerk-signalling",
        "scope": "Public preview visually inspected for composition and detail; no paths copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/1322500/",
        "scope": "Primary abstract/record for domain role and interaction."
      },
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/1411546/",
        "scope": "Primary abstract/record for domain role and interaction."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "egfr-imagegen/sources/mek-ig.png",
      "prompt": "egfr-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "egfr-imagegen/mek-ig.svg",
    "parts": [
      "outline",
      "N-lobe",
      "C-lobe"
    ],
    "anchors": {
      "RAF-substrate": {
        "point": [
          59.62477231329691,
          12.739089250345005
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "binding",
        "interface": {
          "id": "RAF-MEK",
          "shape": "socket",
          "halfWidth": 7.619047619047619,
          "depth": 0.7619047619047619,
          "profile": "continuous-body",
          "framePoint": [
            59.62477231329691,
            12.12386156648451
          ],
          "schematic": true
        }
      },
      "ERK-substrate": {
        "point": [
          102.85245901639345,
          148.21213237777988
        ],
        "normal": [
          0,
          1
        ],
        "kind": "binding",
        "interface": {
          "id": "MEK-ERK",
          "shape": "tab",
          "halfWidth": 7.619047619047619,
          "depth": 0.7619047619047619,
          "profile": "continuous-body",
          "framePoint": [
            102.85245901639345,
            147.62841530054644
          ],
          "schematic": true
        }
      }
    },
    "palette": {
      "outline": "#3D5963",
      "N-lobe": "#69ADB5",
      "C-lobe": "#B3D7CC"
    },
    "source_to_svg": {
      "scale": 0.12386156648451731,
      "translate": [
        7.231329690346087,
        -4.102003642987256
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 1.05,
      "patches": false,
      "source_preserved": true
    }
  },
  {
    "id": "erk-ig",
    "label": "ERK1/2",
    "label_zh": "ERK MAP 激酶",
    "category": "egfr-imagegen",
    "description": "Generated flat mechanism icon for ERK1/2; domain-level teaching schematic.",
    "scope": "Generic teaching geometry. Domain regions and source-pixel contact anchors are curated; no atomic interface is claimed.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/simplified-mapkerk-signalling",
        "scope": "Public preview visually inspected for composition and detail; no paths copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/1411546/",
        "scope": "Primary abstract/record for domain role and interaction."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "egfr-imagegen/sources/erk-ig.png",
      "prompt": "egfr-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "egfr-imagegen/erk-ig.svg",
    "parts": [
      "outline",
      "N-lobe",
      "C-lobe"
    ],
    "anchors": {
      "MEK-substrate": {
        "point": [
          60.88977159880834,
          12.988880930262248
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "binding",
        "interface": {
          "id": "MEK-ERK",
          "shape": "socket",
          "halfWidth": 7.619047619047619,
          "depth": 0.7619047619047619,
          "profile": "continuous-body",
          "framePoint": [
            60.88977159880834,
            12.405163853028796
          ],
          "schematic": true
        }
      }
    },
    "palette": {
      "outline": "#3D5963",
      "N-lobe": "#B2A6CD",
      "C-lobe": "#D7E8EC"
    },
    "source_to_svg": {
      "scale": 0.13505461767626614,
      "translate": [
        1.7358490566037688,
        -14.60575968222443
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 1.05,
      "patches": false,
      "source_preserved": true
    }
  }
]