[
  {
    "id": "pi3k-ig",
    "label": "Class IA PI3K",
    "label_zh": "PI3K",
    "category": "pi3k-akt-imagegen",
    "description": "Class IA p110α–p85α teaching complex; catalytic cleft and accessible regulatory edge.",
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/pi3k-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/2RD0",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      }
    ],
    "file": "pi3k-akt-imagegen/pi3k-ig.svg",
    "parts": [
      "p110-catalytic",
      "p85-regulatory",
      "structural-seams",
      "outline"
    ],
    "anchors": {
      "recruitment": {
        "point": [
          28.137931034482754,
          20.275862068965523
        ],
        "normal": [
          -1.0,
          0.0
        ],
        "kind": "binding"
      },
      "lipid-substrate": {
        "point": [
          105.93103448275862,
          83.3103448275862
        ],
        "normal": [
          1.0,
          0.0
        ],
        "kind": "binding"
      }
    },
    "palette": {
      "outline": "#3D5963",
      "p110-catalytic": "#69ADB5",
      "p85-regulatory": "#E4BE78"
    },
    "source_to_svg": {
      "scale": 0.13793103448275862,
      "translate": [
        -9.379310344827587,
        -6.34482758620689
      ]
    },
    "parts_note": "Semantic fill regions plus curated domain seams and one continuous body outline. They support recoloring; independently moving domains requires rigging the shared contour.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 1,
      "patches": false,
      "source_preserved": true
    },
    "description_zh": "p110α 催化亚基与 p85α 调节亚基，保留可接近的催化与招募边缘。"
  },
  {
    "id": "akt1-ig",
    "label": "AKT1",
    "label_zh": "AKT1",
    "category": "pi3k-akt-imagegen",
    "description": "PH domain, connected kinase and regulatory tail; T308/S473 are external annotation anchors.",
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/akt1-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/3O96",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      },
      {
        "url": "https://www.rcsb.org/structure/1UNQ",
        "inspection": "PH lipid-binding structure metadata read."
      }
    ],
    "file": "pi3k-akt-imagegen/akt1-ig.svg",
    "parts": [
      "kinase",
      "PH",
      "regulatory-tail",
      "structural-seams",
      "outline"
    ],
    "anchors": {
      "lipid-binding": {
        "point": [
          38.80828082808281,
          33.666966696669675
        ],
        "normal": [
          0.0,
          -1.0
        ],
        "kind": "binding"
      },
      "PDK1-contact": {
        "point": [
          87.03870387038704,
          138.89900610572963
        ],
        "normal": [
          0,
          1
        ],
        "kind": "binding",
        "interface": {
          "id": "PDPK1-AKT1",
          "shape": "socket",
          "halfWidth": 3.333333333333333,
          "depth": 0.5555555555555556,
          "profile": "continuous-body",
          "framePoint": [
            87.03870387038704,
            138.45184518451845
          ],
          "schematic": true
        }
      },
      "T308": {
        "point": [
          97.68856885688568,
          136.37083708370835
        ],
        "normal": [
          0.0,
          1.0
        ],
        "kind": "annotation"
      },
      "S473": {
        "point": [
          147.38793879387936,
          125.35373537353736
        ],
        "normal": [
          1.0,
          0.0
        ],
        "kind": "annotation"
      }
    },
    "palette": {
      "outline": "#3D5963",
      "kinase": "#69ADB5",
      "PH": "#E4BE78",
      "regulatory-tail": "#B2A6CD"
    },
    "source_to_svg": {
      "scale": 0.1224122412241224,
      "translate": [
        3.1863186318631875,
        4.043204320432054
      ]
    },
    "parts_note": "Semantic fill regions plus curated domain seams and one continuous body outline. They support recoloring; independently moving domains requires rigging the shared contour.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 0.9,
      "patches": false,
      "source_preserved": true
    },
    "description_zh": "PH 结构域、激酶区和调节尾部相连；T308、S473 标记可在组图时另加。"
  },
  {
    "id": "pten-ig",
    "label": "PTEN",
    "label_zh": "PTEN",
    "category": "pi3k-akt-imagegen",
    "description": "Connected phosphatase and C2 domains with a schematic regulatory tail.",
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/pten-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/1D5R",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      }
    ],
    "file": "pi3k-akt-imagegen/pten-ig.svg",
    "parts": [
      "phosphatase",
      "C2",
      "tail",
      "structural-seams",
      "outline"
    ],
    "anchors": {
      "lipid-substrate": {
        "point": [
          53.135802469135804,
          56.19400352733687
        ],
        "normal": [
          0.0,
          -1.0
        ],
        "kind": "binding"
      },
      "membrane-guide": {
        "point": [
          103.14638447971781,
          46.71957671957672
        ],
        "normal": [
          0.0,
          -1.0
        ],
        "kind": "surface-guide"
      }
    },
    "palette": {
      "outline": "#3D5963",
      "phosphatase": "#69ADB5",
      "C2": "#B3D7CC",
      "tail": "#E4BE78"
    },
    "source_to_svg": {
      "scale": 0.11992945326278659,
      "translate": [
        4.804232804232811,
        3.904761904761912
      ]
    },
    "parts_note": "Semantic fill regions plus curated domain seams and one continuous body outline. They support recoloring; independently moving domains requires rigging the shared contour.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 1,
      "patches": false,
      "source_preserved": true
    },
    "description_zh": "磷酸酶结构域与 C2 膜结合结构域相连，保留短调节尾部。"
  },
  {
    "id": "pdpk1-ig",
    "label": "PDPK1 (PDK1)",
    "label_zh": "PDPK1",
    "category": "pi3k-akt-imagegen",
    "description": "PDPK1 kinase and C-terminal PH domain; this is protein kinase PDK1.",
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/pdpk1-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/5LVO",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      },
      {
        "url": "https://www.rcsb.org/structure/2VKI",
        "inspection": "PH-domain lipid recruitment metadata read; mutant structure, not a wild-type atomic template."
      }
    ],
    "file": "pi3k-akt-imagegen/pdpk1-ig.svg",
    "parts": [
      "kinase",
      "PH",
      "structural-seams",
      "outline"
    ],
    "anchors": {
      "AKT-contact": {
        "point": [
          68.36036036036036,
          18.70942318347342
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "binding",
        "interface": {
          "id": "PDPK1-AKT1",
          "shape": "tab",
          "halfWidth": 3.333333333333333,
          "depth": 0.5555555555555556,
          "profile": "continuous-body",
          "framePoint": [
            68.36036036036036,
            18.26226226226225
          ],
          "schematic": true
        }
      },
      "lipid-binding": {
        "point": [
          136.02002002002,
          90.14214214214213
        ],
        "normal": [
          0.0,
          -1.0
        ],
        "kind": "binding"
      }
    },
    "palette": {
      "outline": "#3D5963",
      "kinase": "#69ADB5",
      "PH": "#E4BE78"
    },
    "source_to_svg": {
      "scale": 0.13613613613613615,
      "translate": [
        -5.2892892892893,
        -4.200200200200214
      ]
    },
    "parts_note": "Semantic fill regions plus curated domain seams and one continuous body outline. They support recoloring; independently moving domains requires rigging the shared contour.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 0.9,
      "patches": false,
      "source_preserved": true
    },
    "description_zh": "左侧为激酶区，右侧为 C 端 PH 结构域。这里的 PDK1 指蛋白激酶 PDPK1。"
  },
  {
    "id": "mtor-ig",
    "label": "mTOR",
    "label_zh": "mTOR",
    "category": "pi3k-akt-imagegen",
    "description": "Open HEAT-repeat scaffold and FAT–kinase region; RHEB site is distal to the substrate cleft.",
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions. One mTOR module; a complete mTORC1 dimer is not represented.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/mtor-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/6BCU",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      }
    ],
    "file": "pi3k-akt-imagegen/mtor-ig.svg",
    "parts": [
      "HEAT-solenoid",
      "FAT-kinase",
      "structural-seams",
      "outline"
    ],
    "anchors": {
      "RAPTOR-contact": {
        "point": [
          62.04355716878403,
          11.938047851976933
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "binding",
        "interface": {
          "id": "mTOR-RAPTOR",
          "shape": "socket",
          "halfWidth": 1.5,
          "depth": 0.25,
          "profile": "continuous-body",
          "framePoint": [
            62.04355716878403,
            12.123411978221416
          ],
          "schematic": true
        }
      },
      "RHEB-contact": {
        "point": [
          29.788066264354594,
          120.47912885662433
        ],
        "normal": [
          -1.0,
          0.0
        ],
        "kind": "binding",
        "interface": {
          "id": "mTOR-RHEB",
          "shape": "socket",
          "halfWidth": 1.5,
          "depth": 0.25,
          "profile": "continuous-body",
          "framePoint": [
            29.95644283121597,
            120.47912885662433
          ],
          "schematic": true
        }
      },
      "mLST8-contact": {
        "point": [
          120.54083484573503,
          141.58383846414452
        ],
        "normal": [
          0.0,
          1.0
        ],
        "kind": "binding",
        "interface": {
          "id": "mTOR-mLST8",
          "shape": "socket",
          "halfWidth": 1.5,
          "depth": 0.25,
          "profile": "continuous-body",
          "framePoint": [
            120.54083484573503,
            141.33575317604357
          ],
          "schematic": true
        }
      },
      "substrate": {
        "point": [
          123.37931034482759,
          112.08711433756807
        ],
        "normal": [
          1.0,
          0.0
        ],
        "kind": "binding"
      }
    },
    "palette": {
      "outline": "#3D5963",
      "HEAT-solenoid": "#69ADB5",
      "FAT-kinase": "#B2A6CD"
    },
    "source_to_svg": {
      "scale": 0.12341197822141561,
      "translate": [
        2.1887477313974557,
        2.620689655172413
      ]
    },
    "parts_note": "Semantic fill regions plus curated domain seams and one continuous body outline. They support recoloring; independently moving domains requires rigging the shared contour.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 2,
      "patches": false,
      "source_preserved": true
    },
    "description_zh": "开放的 HEAT 重复支架连接 FAT–激酶区；RHEB 接触点与底物裂口分开。"
  },
  {
    "id": "raptor-ig",
    "label": "RAPTOR",
    "label_zh": "RAPTOR",
    "category": "pi3k-akt-imagegen",
    "description": "RAPTOR scaffold with a distinct C-terminal WD40 region.",
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/raptor-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/5FLC",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      }
    ],
    "file": "pi3k-akt-imagegen/raptor-ig.svg",
    "parts": [
      "scaffold",
      "WD40",
      "structural-seams",
      "outline"
    ],
    "anchors": {
      "mTOR-contact": {
        "point": [
          20.177006279394803,
          34.44304932735427
        ],
        "normal": [
          -1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "mTOR-RAPTOR",
          "shape": "tab",
          "halfWidth": 3.0,
          "depth": 0.5,
          "profile": "continuous-body",
          "framePoint": [
            19.806278026905836,
            34.44304932735427
          ],
          "schematic": true
        }
      },
      "substrate-recruitment": {
        "point": [
          128.11838565022424,
          144.7067264573991
        ],
        "normal": [
          0.0,
          1.0
        ],
        "kind": "binding"
      }
    },
    "palette": {
      "outline": "#3D5963",
      "scaffold": "#69ADB5",
      "WD40": "#E4BE78"
    },
    "source_to_svg": {
      "scale": 0.12197309417040358,
      "translate": [
        3.461883408071756,
        3.461883408071756
      ]
    },
    "parts_note": "Semantic fill regions plus curated domain seams and one continuous body outline. They support recoloring; independently moving domains requires rigging the shared contour.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 1,
      "patches": false,
      "source_preserved": true
    },
    "description_zh": "弯曲的支架连接 C 端 WD40 区，用于展示 mTORC1 的底物招募组分。"
  },
  {
    "id": "mlst8-ig",
    "label": "mLST8",
    "label_zh": "mLST8",
    "category": "pi3k-akt-imagegen",
    "description": "Seven-bladed WD40 teaching propeller; the colored center is a visual region, not an extra domain.",
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/mlst8-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/5FLC",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      }
    ],
    "file": "pi3k-akt-imagegen/mlst8-ig.svg",
    "parts": [
      "WD40-propeller",
      "propeller-center",
      "structural-seams",
      "outline"
    ],
    "anchors": {
      "mTOR-contact": {
        "point": [
          61.759241706161134,
          28.811785083559258
        ],
        "normal": [
          0.0,
          -1.0
        ],
        "kind": "binding",
        "interface": {
          "id": "mTOR-mLST8",
          "shape": "tab",
          "halfWidth": 5.0,
          "depth": 0.8333333333333334,
          "profile": "continuous-body",
          "framePoint": [
            61.759241706161134,
            27.984834123222747
          ],
          "schematic": true
        }
      }
    },
    "palette": {
      "outline": "#3D5963",
      "WD40-propeller": "#B2A6CD",
      "propeller-center": "#69ADB5"
    },
    "source_to_svg": {
      "scale": 0.12890995260663507,
      "translate": [
        -1.1488151658767833,
        -0.11753554502369923
      ]
    },
    "parts_note": "Semantic fill regions plus curated domain seams and one continuous body outline. They support recoloring; independently moving domains requires rigging the shared contour.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 0.6,
      "patches": false,
      "source_preserved": true
    },
    "description_zh": "七叶 WD40 螺旋桨形示意；中央配色用于辨形，不表示额外结构域。"
  },
  {
    "id": "rheb-ig",
    "label": "RHEB",
    "label_zh": "RHEB",
    "category": "pi3k-akt-imagegen",
    "description": "RHEB GTPase with schematic prenylated tail; nucleotide and activity are separate scene state.",
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/rheb-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/6BSX",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      }
    ],
    "file": "pi3k-akt-imagegen/rheb-ig.svg",
    "parts": [
      "GTPase",
      "prenyl-tail",
      "structural-seams",
      "outline"
    ],
    "anchors": {
      "mTOR-contact": {
        "point": [
          129.3265393251427,
          74.00400801603206
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "mTOR-RHEB",
          "shape": "tab",
          "halfWidth": 4.285714285714286,
          "depth": 0.7142857142857143,
          "profile": "continuous-body",
          "framePoint": [
            129.80761523046093,
            74.00400801603206
          ],
          "schematic": true
        }
      },
      "membrane-guide": {
        "point": [
          28.82965931863727,
          12.13627254509018
        ],
        "normal": [
          -0.7071067811865476,
          -0.7071067811865476
        ],
        "kind": "surface-guide"
      }
    },
    "palette": {
      "outline": "#3D5963",
      "GTPase": "#69ADB5",
      "prenyl-tail": "#E4BE78"
    },
    "source_to_svg": {
      "scale": 0.13627254509018036,
      "translate": [
        -5.647294589178358,
        -3.9438877755511044
      ]
    },
    "parts_note": "Semantic fill regions plus curated domain seams and one continuous body outline. They support recoloring; independently moving domains requires rigging the shared contour.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 0.7,
      "patches": false,
      "source_preserved": true
    },
    "description_zh": "小 GTP 酶与示意性异戊二烯化尾部相连；GDP/GTP 状态由场景另加。"
  }
]