[
  {
    "id": "pi3k-ig",
    "label": "Class IA PI3K",
    "label_zh": "PI3K",
    "category": "pi3k-akt-imagegen",
    "description": "Class IA p110α–p85α teaching complex; catalytic cleft and accessible regulatory edge.",
    "palette": {
      "outline": "#3D5963",
      "p110-catalytic": "#69ADB5",
      "p85-regulatory": "#E4BE78"
    },
    "anchors": {
      "recruitment": {
        "point": [
          272,
          193
        ],
        "normal": [
          -1.0,
          0.0
        ],
        "kind": "binding"
      },
      "lipid-substrate": {
        "point": [
          836,
          650
        ],
        "normal": [
          1.0,
          0.0
        ],
        "kind": "binding"
      }
    },
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/pi3k-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/2RD0",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      }
    ],
    "description_zh": "p110α 催化亚基与 p85α 调节亚基，保留可接近的催化与招募边缘。"
  },
  {
    "id": "akt1-ig",
    "label": "AKT1",
    "label_zh": "AKT1",
    "category": "pi3k-akt-imagegen",
    "description": "PH domain, connected kinase and regulatory tail; T308/S473 are external annotation anchors.",
    "palette": {
      "outline": "#3D5963",
      "kinase": "#69ADB5",
      "PH": "#E4BE78",
      "regulatory-tail": "#B2A6CD"
    },
    "anchors": {
      "lipid-binding": {
        "point": [
          291,
          242
        ],
        "normal": [
          0.0,
          -1.0
        ],
        "kind": "binding"
      },
      "PDK1-contact": {
        "point": [
          685,
          1098
        ],
        "normal": [
          0,
          1
        ],
        "kind": "binding"
      },
      "T308": {
        "point": [
          772,
          1081
        ],
        "normal": [
          0.0,
          1.0
        ],
        "kind": "annotation"
      },
      "S473": {
        "point": [
          1178,
          991
        ],
        "normal": [
          1.0,
          0.0
        ],
        "kind": "annotation"
      }
    },
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/akt1-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/3O96",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      },
      {
        "url": "https://www.rcsb.org/structure/1UNQ",
        "inspection": "PH lipid-binding structure metadata read."
      }
    ],
    "description_zh": "PH 结构域、激酶区和调节尾部相连；T308、S473 标记可在组图时另加。"
  },
  {
    "id": "pten-ig",
    "label": "PTEN",
    "label_zh": "PTEN",
    "category": "pi3k-akt-imagegen",
    "description": "Connected phosphatase and C2 domains with a schematic regulatory tail.",
    "palette": {
      "outline": "#3D5963",
      "phosphatase": "#69ADB5",
      "C2": "#B3D7CC",
      "tail": "#E4BE78"
    },
    "anchors": {
      "lipid-substrate": {
        "point": [
          403,
          436
        ],
        "normal": [
          0.0,
          -1.0
        ],
        "kind": "binding"
      },
      "membrane-guide": {
        "point": [
          820,
          357
        ],
        "normal": [
          0.0,
          -1.0
        ],
        "kind": "surface-guide"
      }
    },
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/pten-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/1D5R",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      }
    ],
    "description_zh": "磷酸酶结构域与 C2 膜结合结构域相连，保留短调节尾部。"
  },
  {
    "id": "pdpk1-ig",
    "label": "PDPK1 (PDK1)",
    "label_zh": "PDPK1",
    "category": "pi3k-akt-imagegen",
    "description": "PDPK1 kinase and C-terminal PH domain; this is protein kinase PDK1.",
    "palette": {
      "outline": "#3D5963",
      "kinase": "#69ADB5",
      "PH": "#E4BE78"
    },
    "anchors": {
      "AKT-contact": {
        "point": [
          541,
          165
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "binding"
      },
      "lipid-binding": {
        "point": [
          1038,
          693
        ],
        "normal": [
          0.0,
          -1.0
        ],
        "kind": "binding"
      }
    },
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/pdpk1-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/5LVO",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      },
      {
        "url": "https://www.rcsb.org/structure/2VKI",
        "inspection": "PH-domain lipid recruitment metadata read; mutant structure, not a wild-type atomic template."
      }
    ],
    "description_zh": "左侧为激酶区，右侧为 C 端 PH 结构域。这里的 PDK1 指蛋白激酶 PDPK1。"
  },
  {
    "id": "mtor-ig",
    "label": "mTOR",
    "label_zh": "mTOR",
    "category": "pi3k-akt-imagegen",
    "description": "Open HEAT-repeat scaffold and FAT–kinase region; RHEB site is distal to the substrate cleft.",
    "palette": {
      "outline": "#3D5963",
      "HEAT-solenoid": "#69ADB5",
      "FAT-kinase": "#B2A6CD"
    },
    "anchors": {
      "RAPTOR-contact": {
        "point": [
          485,
          77
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "binding"
      },
      "RHEB-contact": {
        "point": [
          225,
          955
        ],
        "normal": [
          -1.0,
          0.0
        ],
        "kind": "binding"
      },
      "mLST8-contact": {
        "point": [
          959,
          1124
        ],
        "normal": [
          0.0,
          1.0
        ],
        "kind": "binding"
      },
      "substrate": {
        "point": [
          982,
          887
        ],
        "normal": [
          1.0,
          0.0
        ],
        "kind": "binding"
      }
    },
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions. One mTOR module; a complete mTORC1 dimer is not represented.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/mtor-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/6BCU",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      }
    ],
    "description_zh": "开放的 HEAT 重复支架连接 FAT–激酶区；RHEB 接触点与底物裂口分开。"
  },
  {
    "id": "raptor-ig",
    "label": "RAPTOR",
    "label_zh": "RAPTOR",
    "category": "pi3k-akt-imagegen",
    "description": "RAPTOR scaffold with a distinct C-terminal WD40 region.",
    "palette": {
      "outline": "#3D5963",
      "scaffold": "#69ADB5",
      "WD40": "#E4BE78"
    },
    "anchors": {
      "mTOR-contact": {
        "point": [
          134,
          254
        ],
        "normal": [
          -1,
          0
        ],
        "kind": "binding"
      },
      "substrate-recruitment": {
        "point": [
          1022,
          1158
        ],
        "normal": [
          0.0,
          1.0
        ],
        "kind": "binding"
      }
    },
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/raptor-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/5FLC",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      }
    ],
    "description_zh": "弯曲的支架连接 C 端 WD40 区，用于展示 mTORC1 的底物招募组分。"
  },
  {
    "id": "mlst8-ig",
    "label": "mLST8",
    "label_zh": "mLST8",
    "category": "pi3k-akt-imagegen",
    "description": "Seven-bladed WD40 teaching propeller; the colored center is a visual region, not an extra domain.",
    "palette": {
      "outline": "#3D5963",
      "WD40-propeller": "#B2A6CD",
      "propeller-center": "#69ADB5"
    },
    "anchors": {
      "mTOR-contact": {
        "point": [
          488,
          218
        ],
        "normal": [
          0.0,
          -1.0
        ],
        "kind": "binding"
      }
    },
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/mlst8-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/5FLC",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      }
    ],
    "description_zh": "七叶 WD40 螺旋桨形示意；中央配色用于辨形，不表示额外结构域。"
  },
  {
    "id": "rheb-ig",
    "label": "RHEB",
    "label_zh": "RHEB",
    "category": "pi3k-akt-imagegen",
    "description": "RHEB GTPase with schematic prenylated tail; nucleotide and activity are separate scene state.",
    "palette": {
      "outline": "#3D5963",
      "GTPase": "#69ADB5",
      "prenyl-tail": "#E4BE78"
    },
    "anchors": {
      "mTOR-contact": {
        "point": [
          994,
          572
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding"
      },
      "membrane-guide": {
        "point": [
          253,
          118
        ],
        "normal": [
          -0.7071067811865476,
          -0.7071067811865476
        ],
        "kind": "surface-guide"
      }
    },
    "scope": "Domain-level educational schematic; contacts and residue anchors are illustrative, not atomic positions.",
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "pi3k-akt-imagegen/sources/rheb-ig.png",
      "prompt": "pi3k-akt-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/pi3k-pathway-in-cancer",
        "inspection": "Public preview visually inspected; flat pathway style only. No art copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://www.rcsb.org/structure/6BSX",
        "inspection": "Structure metadata and primary-publication summary read; coordinates not used to trace geometry."
      }
    ],
    "description_zh": "小 GTP 酶与示意性异戊二烯化尾部相连；GDP/GTP 状态由场景另加。"
  }
]