[
  {
    "id": "tgfb1-ig",
    "label": "TGFβ1 dimer",
    "label_zh": "TGFβ1 dimer",
    "category": "tgfb-imagegen",
    "description": "Mature ligand homodimer; latent-complex proteins omitted.",
    "scope": "Mature ligand homodimer; latent-complex proteins omitted. Contact contours are illustrative.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/tgf-beta-signaling-pathway",
        "scope": "Public full preview visually inspected; no artwork copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/20207738/",
        "scope": "Primary abstract and available figure captions read."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "tgfb-imagegen/sources/tgfb1-ig.png",
      "prompt": "tgfb-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "tgfb-imagegen/tgfb1-ig.svg",
    "parts": [
      "outline",
      "subunit-a",
      "subunit-b"
    ],
    "anchors": {
      "II-left": {
        "point": [
          25.599999999999998,
          80.36938386967074
        ],
        "normal": [
          0,
          1
        ],
        "kind": "binding",
        "interface": {
          "id": "TGFB-RII",
          "shape": "tab",
          "halfWidth": 9.090909090909092,
          "depth": 0.30303030303030304,
          "profile": "continuous-body",
          "framePoint": [
            25.599999999999998,
            80.13963039014374
          ],
          "schematic": true
        }
      },
      "II-right": {
        "point": [
          134.40000000000003,
          80.36938386967074
        ],
        "normal": [
          0,
          1
        ],
        "kind": "binding",
        "interface": {
          "id": "TGFB-RII",
          "shape": "tab",
          "halfWidth": 9.090909090909092,
          "depth": 0.30303030303030304,
          "profile": "continuous-body",
          "framePoint": [
            134.40000000000003,
            80.13963039014374
          ],
          "schematic": true
        }
      },
      "I-left": {
        "point": [
          59.59999999999999,
          96.29696629251794
        ],
        "normal": [
          0,
          1
        ],
        "kind": "binding",
        "interface": {
          "id": "TGFB-RI",
          "shape": "tab",
          "halfWidth": 0.9090909090909092,
          "depth": 0.21212121212121213,
          "profile": "continuous-body",
          "framePoint": [
            59.59999999999999,
            96.10403832991102
          ],
          "schematic": true
        }
      },
      "I-right": {
        "point": [
          100.4,
          96.29696629251794
        ],
        "normal": [
          0,
          1
        ],
        "kind": "binding",
        "interface": {
          "id": "TGFB-RI",
          "shape": "tab",
          "halfWidth": 0.9090909090909092,
          "depth": 0.21212121212121213,
          "profile": "continuous-body",
          "framePoint": [
            100.4,
            96.10403832991102
          ],
          "schematic": true
        }
      }
    },
    "palette": {
      "outline": "#3D5963",
      "subunit-a": "#E4BE78",
      "subunit-b": "#B3D7CC"
    },
    "source_to_svg": {
      "scale": 0.09308692676249145,
      "translate": [
        -2.6146475017111612,
        37.97125256673511
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 3.3,
      "patches": false,
      "source_preserved": true
    }
  },
  {
    "id": "tgfbr2-ig",
    "label": "TGFβRII",
    "label_zh": "TGFβRII",
    "category": "tgfb-imagegen",
    "description": "Single-pass type II receptor with constitutive kinase activity; teaching domain proportions.",
    "scope": "Single-pass type II receptor with constitutive kinase activity; teaching domain proportions. Contact contours are illustrative.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/tgf-beta-signaling-pathway",
        "scope": "Public full preview visually inspected; no artwork copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/8047140/",
        "scope": "Primary abstract and available figure captions read."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "tgfb-imagegen/sources/tgfbr2-ig.png",
      "prompt": "tgfb-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "tgfb-imagegen/tgfbr2-ig.svg",
    "parts": [
      "outline",
      "ectodomain-stalk",
      "kinase"
    ],
    "anchors": {
      "ligand": {
        "point": [
          80.0,
          17.559553364128128
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "binding",
        "interface": {
          "id": "TGFB-RII",
          "shape": "socket",
          "halfWidth": 12.5,
          "depth": 0.4166666666666667,
          "profile": "continuous-body",
          "framePoint": [
            80.0,
            17.243642329778506
          ],
          "schematic": true
        }
      },
      "membrane": {
        "point": [
          80.0,
          61.639999999999986
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "membrane"
      },
      "SMAD-substrate": {
        "point": [
          84.57424118129614,
          116.72000000000001
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding"
      },
      "GS-activation": {
        "point": [
          96.73502871205906,
          99.03999999999999
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding"
      }
    },
    "palette": {
      "outline": "#3D5963",
      "ectodomain-stalk": "#69ADB5",
      "kinase": "#B2A6CD"
    },
    "source_to_svg": {
      "scale": 0.11156685808039377,
      "translate": [
        20.088597210828546,
        -6.29696472518458
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 2.4,
      "patches": false,
      "source_preserved": true
    }
  },
  {
    "id": "tgfbr1-ig",
    "label": "TGFβRI / ALK5",
    "label_zh": "TGFβRI / ALK5",
    "category": "tgfb-imagegen",
    "description": "Single-pass type I receptor, membrane-proximal GS region and Ser/Thr kinase.",
    "scope": "Single-pass type I receptor, membrane-proximal GS region and Ser/Thr kinase. Contact contours are illustrative.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/tgf-beta-signaling-pathway",
        "scope": "Public full preview visually inspected; no artwork copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/8047140/",
        "scope": "Primary abstract and available figure captions read."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "tgfb-imagegen/sources/tgfbr1-ig.png",
      "prompt": "tgfb-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "tgfb-imagegen/tgfbr1-ig.svg",
    "parts": [
      "outline",
      "ectodomain-stalk",
      "GS-region",
      "kinase"
    ],
    "anchors": {
      "ligand": {
        "point": [
          80.0,
          13.548922589845048
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "binding",
        "interface": {
          "id": "TGFB-RI",
          "shape": "socket",
          "halfWidth": 2.710270080117064,
          "depth": 0.6323963520273149,
          "profile": "continuous-body",
          "framePoint": [
            80.0,
            12.97374701670645
          ],
          "schematic": true
        }
      },
      "membrane": {
        "point": [
          80.0,
          61.640000000000015
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "membrane"
      },
      "SMAD-substrate": {
        "point": [
          90.73509883745918,
          116.71999999999998
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "MH2-association",
          "shape": "socket",
          "halfWidth": 4.517116800195107,
          "depth": 0.22585584000975537,
          "profile": "continuous-body",
          "framePoint": [
            90.92760540970565,
            116.71999999999998
          ],
          "schematic": true
        }
      },
      "GS-activation": {
        "point": [
          89.08830548926014,
          99.04
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding"
      },
      "GS": {
        "point": [
          73.50835322195704,
          86.80000000000001
        ],
        "normal": [
          -1,
          0
        ],
        "kind": "binding"
      }
    },
    "palette": {
      "outline": "#3D5963",
      "ectodomain-stalk": "#69ADB5",
      "GS-region": "#E4BE78",
      "kinase": "#B2A6CD"
    },
    "source_to_svg": {
      "scale": 0.10819411296738266,
      "translate": [
        23.198090692124104,
        -4.337311058074775
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 1.1069007557617363,
      "patches": false,
      "source_preserved": true
    }
  },
  {
    "id": "smad3-ig",
    "label": "SMAD3",
    "label_zh": "SMAD3",
    "category": "tgfb-imagegen",
    "description": "MH1, linker, MH2 and C-terminal phosphorylation tail; not a solved surface.",
    "scope": "MH1, linker, MH2 and C-terminal phosphorylation tail; not a solved surface. Contact contours are illustrative.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/tgf-beta-signaling-pathway",
        "scope": "Public full preview visually inspected; no artwork copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/15350224/",
        "scope": "Primary abstract and available figure captions read."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "tgfb-imagegen/sources/smad3-ig.png",
      "prompt": "tgfb-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "tgfb-imagegen/smad3-ig.svg",
    "parts": [
      "outline",
      "MH1",
      "MH2",
      "SSXS-tail"
    ],
    "anchors": {
      "co-SMAD-right": {
        "point": [
          123.16835827941631,
          99.04
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "MH2-association",
          "shape": "tab",
          "halfWidth": 7.692307692307692,
          "depth": 0.3846153846153846,
          "profile": "continuous-body",
          "framePoint": [
            122.84053417124903,
            99.04
          ],
          "schematic": true
        }
      },
      "co-SMAD-left": {
        "point": [
          36.7248074707801,
          99.04
        ],
        "normal": [
          -1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "MH2-association",
          "shape": "tab",
          "halfWidth": 7.692307692307692,
          "depth": 0.3846153846153846,
          "profile": "continuous-body",
          "framePoint": [
            37.05263157894737,
            99.04
          ],
          "schematic": true
        }
      },
      "receptor-docking": {
        "point": [
          37.05263157894737,
          104.48000000000002
        ],
        "normal": [
          -1,
          0
        ],
        "kind": "binding"
      },
      "DNA-binding": {
        "point": [
          80.0,
          23.965435978004717
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "binding"
      },
      "center": {
        "point": [
          80.0,
          80.0
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "center"
      },
      "SSXS-tail": {
        "point": [
          80.0,
          147.8931657501964
        ],
        "normal": [
          0,
          1
        ],
        "kind": "binding"
      }
    },
    "palette": {
      "outline": "#3D5963",
      "MH1": "#69ADB5",
      "MH2": "#B2A6CD",
      "SSXS-tail": "#E4BE78"
    },
    "source_to_svg": {
      "scale": 0.10683424980361352,
      "translate": [
        25.30086410054988,
        -2.2089552238805936
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 0.65,
      "patches": false,
      "source_preserved": true
    }
  },
  {
    "id": "smad4-ig",
    "label": "SMAD4",
    "label_zh": "SMAD4",
    "category": "tgfb-imagegen",
    "description": "Co-SMAD with MH1/linker/MH2; no R-SMAD SSXS activation motif.",
    "scope": "Co-SMAD with MH1/linker/MH2; no R-SMAD SSXS activation motif. Contact contours are illustrative.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/tgf-beta-signaling-pathway",
        "scope": "Public full preview visually inspected; no artwork copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://pubmed.ncbi.nlm.nih.gov/15350224/",
        "scope": "Primary abstract and available figure captions read."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "tgfb-imagegen/sources/smad4-ig.png",
      "prompt": "tgfb-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "tgfb-imagegen/smad4-ig.svg",
    "parts": [
      "outline",
      "MH1",
      "MH2"
    ],
    "anchors": {
      "co-SMAD-right": {
        "point": [
          123.29193637087462,
          99.04
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "MH2-association",
          "shape": "socket",
          "halfWidth": 7.692307692307692,
          "depth": 0.3846153846153846,
          "profile": "continuous-body",
          "framePoint": [
            123.6197604790419,
            99.04
          ],
          "schematic": true
        }
      },
      "co-SMAD-left": {
        "point": [
          36.50447081475409,
          99.04
        ],
        "normal": [
          -1,
          0
        ],
        "kind": "binding",
        "interface": {
          "id": "MH2-association",
          "shape": "socket",
          "halfWidth": 7.692307692307692,
          "depth": 0.3846153846153846,
          "profile": "continuous-body",
          "framePoint": [
            36.17664670658682,
            99.04
          ],
          "schematic": true
        }
      },
      "receptor-docking": {
        "point": [
          35.05688622754491,
          104.48
        ],
        "normal": [
          -1,
          0
        ],
        "kind": "binding"
      },
      "DNA-binding": {
        "point": [
          80.0,
          12.50898203592815
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "binding"
      },
      "center": {
        "point": [
          80.0,
          80.0
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "center"
      }
    },
    "palette": {
      "outline": "#3D5963",
      "MH1": "#B3D7CC",
      "MH2": "#69ADB5"
    },
    "source_to_svg": {
      "scale": 0.10179640718562874,
      "translate": [
        27.82934131736527,
        1.7185628742515036
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 0.65,
      "patches": false,
      "source_preserved": true
    }
  },
  {
    "id": "smad2-ig",
    "label": "SMAD2",
    "label_zh": "SMAD2",
    "category": "tgfb-imagegen",
    "description": "SMAD2-specific MH1 insertion shown schematically; library extension, not the SMAD3 lesson actor.",
    "scope": "SMAD2-specific MH1 insertion shown schematically; library extension, not the SMAD3 lesson actor. Contact contours are illustrative.",
    "visual_references": [
      {
        "url": "https://www.biorender.com/template/tgf-beta-signaling-pathway",
        "scope": "Public full preview visually inspected; no artwork copied."
      }
    ],
    "scientific_references": [
      {
        "url": "https://doi.org/10.1074/jbc.272.44.28107",
        "scope": "Primary abstract and available figure captions read."
      }
    ],
    "provenance": {
      "mode": "built-in-imagegen-traced",
      "source": "tgfb-imagegen/sources/smad2-ig.png",
      "prompt": "tgfb-imagegen/prompts.json",
      "license": "MIT",
      "generator_model": "tool-managed; identifier not exposed"
    },
    "file": "tgfb-imagegen/smad2-ig.svg",
    "parts": [
      "outline",
      "MH1-insertion",
      "MH2",
      "SSXS-tail"
    ],
    "anchors": {
      "co-SMAD-right": {
        "point": [
          121.42105263157895,
          99.03999999999999
        ],
        "normal": [
          1,
          0
        ],
        "kind": "binding"
      },
      "co-SMAD-left": {
        "point": [
          38.473684210526315,
          99.03999999999999
        ],
        "normal": [
          -1,
          0
        ],
        "kind": "binding"
      },
      "receptor-docking": {
        "point": [
          37.631578947368425,
          104.48
        ],
        "normal": [
          -1,
          0
        ],
        "kind": "binding"
      },
      "DNA-binding": {
        "point": [
          80.0,
          24.21052631578947
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "binding"
      },
      "center": {
        "point": [
          80.0,
          80.0
        ],
        "normal": [
          0,
          -1
        ],
        "kind": "center"
      },
      "SSXS-tail": {
        "point": [
          80.0,
          147.68421052631578
        ],
        "normal": [
          0,
          1
        ],
        "kind": "binding"
      }
    },
    "palette": {
      "outline": "#3D5963",
      "MH1-insertion": "#D7E8EC",
      "MH2": "#B2A6CD",
      "SSXS-tail": "#E4BE78"
    },
    "source_to_svg": {
      "scale": 0.10526315789473684,
      "translate": [
        26.05263157894737,
        -3.05263157894737
      ]
    },
    "parts_note": "Color-assisted semantic fill groups; shared outline paths retain paint order. Curate extra motion parts separately.",
    "contour_refinement": {
      "method": "closed-cubic-body",
      "outer_line": 1.6,
      "inner_line": 1.1,
      "scale_at_assembly": 1,
      "patches": false,
      "source_preserved": true
    }
  }
]
